How Digital Medicine Will Soon Save Your Life You wake up with chest pain. Your smartphone reads your ECG. If it’s a heart attack, it calls an ambulance and sends your data ahead to the ER.

Robin Cook & Eric Topol:

A sweeping transformation of medicine has begun that will rival in importance the introduction of anesthesia or the discovery of the germ basis of infectious disease. It will change how patients and physicians interact. It will change medical research and therapy. “Sick care”—the current model of waiting for you to get sick and then trying to alleviate symptoms and make you well—will become true “health care,” where prevention is the mantra and driving force. Welcome to the world of digital medicine.

First and foremost, the digitalization of medicine will personalize health care: Treatment will be tailored to each person as a unique individual suffering a unique illness according to his or her genetic makeup. Currently, therapy is based on population statistics. Patients are separated into groups defined in various ways but usually by similar symptoms or by the results of basic lab tests (like cholesterol levels). These groups are then treated with drugs that may help many people, but not all of them, and often only a fraction of them. By incorporating information from an individual’s DNA, the data made available through digitalization will enable clinicians to match individuals with treatments. Only patients who will benefit will get a particular drug.

Impossible Cities

Darran Anderson:

In 1298, the Venetian merchant and explorer Marco Polo found himself in a Genoese prison, having been seized at the helm of a war galley during the Battle of Curzola. There he met the chivalric writer Rustichello of Pisa to whom he related tales of his travels along the Silk Road into Asia in the previous decades. The resulting manuscript The Description of the World or The Travels of Marco Polo became a literary sensation, being reproduced across Medieval Europe. Such were the extravagant claims in this “great book of puzzles”, many were taken to be fabrications and Polo earned the nickname “the Man of a Million Lies”. It was doubted by some that he’d even travelled at all except around his own evidently vast imagination.

The accounts did however contain many genuine discoveries alongside exaggerations, half-truths and myths (‘How the Prayer of the One-Eyed Cobbler Caused the Mountain to Move’ for example) mixed together without differentiation. We can now pour scorn on his claims of desert sirens luring the unwary to their deaths, colossal birds who fed on elephants, idolaters “adept in sorceries and diabolical arts” who could control sandstorms or witnessing Noah’s Ark perched on a mountaintop where the snow never melts. At the time, these were scarcely more unbelievable than his claims of “stones that burn like logs” (coal), paper currency, seeing the highest mountains in the world (the Himalayas) or visiting vast golden cities hung with the finest silks yet we know these now to be fairly accurate descriptions.

The backbone of Polo’s travelogue is made up of his visits to various Oriental cities (Baudas, Samarcan, Caracoron and so on) culminating in the opulent palaces of the Chinese Mongol Emperor Kublai Khan, at whose court he was a guest for 17 years. His recollections of the centres and their populaces range from the mercantile (lists of industries and natural resources) to the fanciful; cities where the inhabitants are perpetually drunk, where men ride around on stags eating birds, where marriages are arranged between ghosts or the great Kaan in his marble palace drinks wine from levitating goblets. Often Polo would add boasts and hyperbole (“no one could imagine finer” is a recurring phrase) and even suggest he was holding back for fear of arousing incredulity in the readers (“I will relate none of this in this book of ours; people would be amazed if they heard it, but it would serve no good purpose”) which only served to further his ridicule. When he was on his deathbed, a priest giving last rites asked Polo if he wished to confess to exaggerating his recollections to which he replied, “I did not reveal half of what I saw because no one would have believed me.” Beyond their narrow confines, the world was more extraordinary than his sceptics were capable of imagining. Raised in the seemingly impossible ‘floating city’ of Venice, a maze of canals and alleys built on stilts in a lagoon, Marco Polo had no such limitations.

Asymcar 10: Asleep at the Switch

The orthodox vs. the unorthodox: Tata, Tesla and Toyota. Why might an asymmetric competitor lose and a symmetric competitor win?
 
 We begin with Tesla and Apple. We continue with aluminum vehicles and re-visit information asymmetry as Horace exploits it to buy a Mercedes on eBay.
 
 We talk about car APIs (Aux input jack and ODBII) and much, much more.
 
 A brief discussion considers the perils of endless line extension up and down the market, perhaps fueled by financialization.
 
 This is a good one.
 
 Asymcar 10: Asleep at the switch | Asymcar.